Turning back time with emerging rejuvenation strategies
Ageing is associated with the functional decline of all tissues and a striking increase in many diseases. Although ageing has long been considered a one-way street, strategies to delay and potentially even reverse the ageing process have recently been developed. Here, we review four emerging rejuvenation strategies—systemic factors, metabolic manipulations, senescent cell ablation and cellular reprogramming—and discuss their mechanisms of action, cellular targets, potential trade-offs and application to human ageing.
Blue Zones
Age Reversal Network
The purpose of the Age Reversal Network is to exchange scientific information, foster strategic alliances, and support biomedical endeavors aimed at reversing degenerative aging.
We unite people in ways that will accelerate the availability of rejuvenation technologies to benefit all of humanity, including members of the group. As data emerges, the Age Reversal Network will seek to rapidly convey this to members of our private association.
Summary: Ozone Therapy Health Benefits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674660/
Conclusions
O3 therapy can alter the natural history of several disease and disorders, with potentially many more yet untested. A plethora of laboratory studies have provided evidence of O3's antioxidant capabilities, as well as vascular, hematological, and immune system modulations. This evidence has been further substantiated in clinical trials with O3 therapy being useful in the cardiovascular, subcutaneous tissue, peripheral vascular disease, neurological, head and neck, orthopedic, gastrointestinal, and genitourinary pathologies. O3therapy has proven especially beneficial in the diabetic foot, ischemic wounds, and peripheral vascular disease, areas in which O3 use is most prevalent. Upcoming laboratory and translational research should begin to develop protocols for O3-AHT in attempts to establish a dose-response relationship as it has demonstrated high utility in a myriad of pathologies at varying concentrations. Despite the presently compelling evidence, future studies should include more double-blind, randomized clinical trials with greater sample sizes, determination of longevity in benefits produced, as well as methods of measurements and analysis.